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Werner syndrome RecQ helicase-IN-3

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Chemical Structure| 2869954-98-1 同义名 : -
CAS号 : 2869954-98-1
货号 : A1937129
分子式 : C31H30ClF3N8O5
纯度 : 98%
分子量 : 687.069
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(87.33 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Werner syndrome RecQ helicase-IN-3 is a potent and orally active inhibitor of Werner syndrome RecQ helicase (WRN), with an IC50 value of 0.06 µM. It exhibits antiproliferative and anticancer activities[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.46mL

0.29mL

0.15mL

7.28mL

1.46mL

0.73mL

14.55mL

2.91mL

1.46mL
参考文献

[1]Vincent Bordas, et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060A1.

[2]Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.