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Luzindole

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Chemical Structure| 117946-91-5 同义名 : N-0774
CAS号 : 117946-91-5
货号 : A192769
分子式 : C19H20N2O
纯度 : 98%
分子量 : 292.375
MDL号 : MFCD00672498
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(359.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Luzindole, identified as N-0774, acts as a melatonin receptor blocker with a higher affinity for MT2 (Mel1b) receptors compared to MT1 (Mel1a), demonstrated by Ki values of 10.2 nM for MT2 and 158 nM for MT1. It has been found to inhibit the progression of experimental autoimmune encephalomyelitis (EAE) and display properties akin to antidepressants[1][2][3]. Additionally, Luzindole at concentrations ranging from 5-10 μg/ml effectively hinders the antigen-specific growth of the MBP-responsive LV-4 T cell line[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.42mL

0.68mL

0.34mL

17.10mL

3.42mL

1.71mL

34.20mL

6.84mL

3.42mL
参考文献

[1]Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Ph

[2]Constantinescu CS, et al. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology. 1997;65(4):190-4.

[3]Dubocovich ML Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test. Eur J Pharmacol. 1990 Jul 3;182(2):313-25.