KPT-276

产品说明书

Print
Chemical Structure| 1421919-75-6 同义名 : -
CAS号 : 1421919-75-6
货号 : A192347
分子式 : C16H10F8N4O
纯度 : 99%+
分子量 : 426.264
MDL号 : MFCD27937049
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(42.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

30% PEG400+0.5% Tween80+5% propylene glycol+water 5 mg/mL suspension

生物活性
靶点

  • CRM1
描述 KT-276 is a derivative of PKT-185, designed as an orally available and selective inhibitor targeting the nuclear export (SINE) function. Specifically, it acts as a CRM1 antagonist, irreversibly binding to and inhibiting the CRM1 protein, which plays a crucial role in the nuclear export of numerous proteins and RNA[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.23mL

11.73mL

2.35mL

1.17mL

23.46mL

4.69mL

2.35mL
参考文献

[1]Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120(9):1765-73.