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Tenofovir alafenamide hemifumarate

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Chemical Structure| 1392275-56-7 同义名 : 半富马酸替诺福韦艾拉酚胺 ;GS-7340 hemifumarate;TAF hemifumarate
CAS号 : 1392275-56-7
货号 : A192211
分子式 : C46H62N12O14P2
纯度 : 99+%
分子量 : 1069.004
MDL号 : MFCD30534429
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(46.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(18.71 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) exhibits consistent antiviral efficacy across various cell types, with potency ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.94mL

0.19mL

0.09mL

4.68mL

0.94mL

0.47mL

9.35mL

1.87mL

0.94mL
参考文献

[1]Birkus G, et al. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors. Antimicrob Agents Chemother. 2015 Oct 26;60(1):316-22.

[2]Callebaut C, et al. In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2015 Oct;59(10):5909-16.