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H-Cit-OH

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Chemical Structure| 372-75-8 同义名 : L-瓜氨酸 ;N5-Carbamoyl Ornithine;NSC 27425;delta-Ureidonorvaline.;Sitrulline;L-Cytrulline;Citrulline
CAS号 : 372-75-8
货号 : A192054
分子式 : C6H13N3O3
纯度 : 98%
分子量 : 175.186
MDL号 : MFCD00064397
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(285.41 mM)
动物实验配方：
生物活性
描述 H-Cit-OH, found in watermelon, is a precursor of l-arginine and nitric oxide (NO) in vivo [1-2] . In vivo studies, H-Cit-OH could protect skeletal muscle cell size through mediating iNOS mRNA expression in skeletal muscle cells [3] . Besides this, it was found that H-Cit-OH could protect airway epithelial cells against the decreasing of NO and the increasing of oxidative and nitrosative stress induced by increasing ADMA [4] . In vivo studies, H-Cit-OH has the ability of promoting the fetal growth in rats with Intrauterine growth restriction (IUGR), probably through enhancing fetal muscle protein synthesis and/or increasing NO production [2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.71mL

1.14mL

0.57mL

28.54mL

5.71mL

2.85mL

57.08mL

11.42mL

5.71mL
参考文献

[1]Figueroa A, Wong A, et al. Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Curr Opin Clin Nutr Metab Care. 2017;20(1):92-98.

[2]Bourdon A, Parnet P, et al. L-Citrulline Supplementation Enhances Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction. J Nutr. 2016;146(3):532-41.

[3]Ham DJ, Gleeson BG, et al. L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. PLoS One. 2015;10(10):e0141572.

[4]Winnica D, Que LG, et al. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017;47(2):190-199.