产品说明书

Rolapitant

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Chemical Structure| 552292-08-7 同义名 : 罗拉吡坦 ;SCH619734
CAS号 : 552292-08-7
货号 : A190999
分子式 : C25H26F6N2O2
纯度 : 98%
分子量 : 500.477
MDL号 : MFCD23105917
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(59.94 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rolapitant inhibits CYP2D6, breast cancer resistance protein (BCRP), and Neurokinin (NK)1 Receptor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

9.99mL

2.00mL

1.00mL

19.98mL

4.00mL

2.00mL
参考文献

[1]Rapaport BL. Rolapitant: A NK-1 Receptor Antagonist for the Prevention of Chemotherapy-Induced Nausea and Vomiting. Rev Recent Clin Trials. 2017 Apr 6.

[2]Rapoport B, Schwartzberg L, et al. Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy. Eur J Cancer. 2016 Apr;57:23-30.