Etonogestrel
产品说明书
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同义名 : | 3-keto-Desogestrel; 3-Oxodesogestrel; Etonogestrel, Implanon, nexplanon, 3-keto-desogestrel, 3-ketodesogestrel, 3-oxo desogestrel, 3-oxodesogestrel; ORG 3236; Nexplanon; Implanon |
| CAS号 : | 54048-10-1 | |
| 货号 : | A190908 | |
| 分子式 : | C22H28O2 | |
| 纯度 : | 98% | |
| 分子量 : | 324.46 | |
| MDL号 : | MFCD00867863 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(154.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. FKBP51 is a repressor of PR/GR transcriptional activity, whose protein level are increased significantly in human endometrial stromal cells (HESCs) in response to estradiol (10−8 M) + etonogestrel (10−7 M) or estradiol + medroxyprogesterone acetate (10−7 M), but not to estradiol + progesterone (10−7 M)[3]. Etonogestrel subcutaneous implants in rats increased apoptotic index and Hscore values in stroma and glandular epithelium of uterus, granulosa and teca-lutein cells of the ovary with the longer progesterone exposure[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03264781 | Uterine Bleeding | Phase 1 Phase 2 | Recruiting | December 2017 | Thailand ... 展开 >> Chulalongkorn Hospital Recruiting Bangkok, Thailand Contact: Nitisa Tapanwong, MD nitisa.tapanwong@gmail.com 收起 << |
| NCT02367833 | Bone; Disorder, Development an... 展开 >>d Growth 收起 << | Phase 4 | Active, not recruiting | December 2018 | United States, Pennsylvania ... 展开 >> Women's Health and Exercise Laboratories, The Pennsylvania State University University Park, Pennsylvania, United States, 16802 收起 << |
| NCT01174225 | Contraception | Phase 4 | Active, not recruiting | December 2020 | Canada, British Columbia ... 展开 >> Kelowna Womens' Clinic Kelowna, British Columbia, Canada 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.08mL 0.62mL 0.31mL |
15.41mL 3.08mL 1.54mL |
30.82mL 6.16mL 3.08mL |
| 参考文献 |
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