产品说明书
Baclofen
 |
同义名 : | 巴氯酚 ;(±)-Baclofen |
| CAS号 : | 1134-47-0 | |
| 货号 : | A190802 | |
| 分子式 : | C10H12ClNO2 | |
| 纯度 : | 98% | |
| 分子量 : | 213.661 | |
| MDL号 : | MFCD00055143 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 4 mg/mL(18.72 mM)，配合低频超声，水浴加热至45℃，并调节pH至4，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2 mg/mL(9.36 mM)，配合低频超声助溶 0.1 M HCL: 10 mg/mL(46.8 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA-B receptor (GABABR) agonist. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[3]. Intrathecal baclofen infusion is an accepted treatment for spasticity[4]. Baclofen pretreatment (3 mg/kg) not only prolonged the time taken for animals to reach a core body temperature of 40 degrees C[5]. Moreover, repeated pretreatment attenuates baclofen-attributed neurotoxicity in overdose and results in post-discontinuation withdrawal syndrome[6]. In high-dose baclofen participants only, there was a predictive effect of lower baseline heart rate variability and fewer post-test percentage of heavy drinking days. There was a dose-specific rescuing effect of high-dose baclofen on the dynamic modulation of cardiovascular responses to eliciting cues[7]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00814632 | Vulvodynia | Phase 2 | Completed | - | United States, Michigan ... 展开 >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 收起 << |
| NCT01244113 | Cerebral Palsy | Not Applicable | Completed | - | Korea, Republic of ... 展开 >> Severance Hospital Seoul, Korea, Republic of, 120-752 收起 << |
| NCT02771925 | Alcohol Dependence | Phase 4 | Unknown | May 2018 | India ... 展开 >> Dyanand Medical College and Hospital Recruiting Ludhiana, Punjab, India, 141001 Contact: Sandeep Singh Sidhu, MD,DM +919814025085 sandeepsidhu1963@gmail.com Contact: Omesh Goyal, MD,DM +919914821155 goyalomesh@yahoo.co.in Principal Investigator: Sandeep Singh Sidhu, MD,DM 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.68mL 0.94mL 0.47mL |
23.40mL 4.68mL 2.34mL |
46.80mL 9.36mL 4.68mL |
| 参考文献 |
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