AUZ 454

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Chemical Structure| 853299-07-7 同义名 : K03861
CAS号 : 853299-07-7
货号 : A190561
分子式 : C24H26F3N7O2
纯度 : 99%+
分子量 : 501.504
MDL号 : MFCD19443769
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(498.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • CDK2

    CDK2(A144C), Kd:9.7 nM

    CDK2(C118L), Kd:18.6 nM
描述 AUZ 454 (K03861) (10-20 μM; 1, 2, 3, and 4 days) exerts an inhibitory effect on Caki-1 and ACHN cells with WTAP overexpression, as demonstrated by CCK8 assays[2]. Through a CDK2-dependent mechanism, AUZ 454 (K03861) (10 μM; 24 hours) decreases colony formation in Caki-1 and ACHN cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.97mL

1.99mL

1.00mL

19.94mL

3.99mL

1.99mL
参考文献

[1]Tang J,et al. Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability.J Exp Clin Cancer Res. 2018 Feb 27;37(1):40.

[2]Strande JL, et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Basic Res Cardiol. 2007 Jul;102(4):350-8.