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Anacardic Acid

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Chemical Structure| 16611-84-0 同义名 : 2-羟基-6-十五基苯甲酸 ;Ginkgolic Acid C15:0;Hydroginkgolic acid;6-pentadecylsalicylic Acid
CAS号 : 16611-84-0
货号 : A190197
分子式 : C22H36O3
纯度 : 99%+
分子量 : 348.519
MDL号 : MFCD07368254
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(301.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+40%PEG300+5% tween80+50% water 8 mg/mL

生物活性
靶点

  • p300/CBP

    PCAF, IC50:5 μM

    p300/CBP, IC50:8.5 μM
描述 Anacardic acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
HCT116 cells Cytotoxicity assay 72 h Cytotoxicity against human HCT116 cells after 72 hrs by luciferase reporter gene assay, IC50=0.38 μM 23245311
Hi5 cells Function assay Non-competitive inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells 23245311
Hi5 cells Function assay Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay, IC50=0.024 μM 23245311
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.87mL

0.57mL

0.29mL

14.35mL

2.87mL

1.43mL

28.69mL

5.74mL

2.87mL
参考文献

[1]Sun Y, Jiang X, Chen S, et al. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006 Aug 7;580(18):4353-6.

[2]Balasubramanyam K, Swaminathan V, et al. Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003 May 23;278(21):19134-40.