产品说明书

Zidesamtinib

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Chemical Structure| 2739829-00-4 同义名 : NVL-520
CAS号 : 2739829-00-4
货号 : A1901672
分子式 : C22H22FN7O
纯度 : 99%+
分子量 : 419.455
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(119.2 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Zidesamtinib (NVL-520) is an orally active, brain-penetrant inhibitor that demonstrates potent selectivity against various ROS1 fusions and resistance mutations. It exhibits IC50 values of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, while sparing TRK inhibition. Zidesamtinib serves as a valuable tool for cancer research [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.92mL

2.38mL

1.19mL

23.84mL

4.77mL

2.38mL
参考文献

[1]Drilon A, et, al. NVL-520 is a selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations. Cancer Discov. 2022 Dec 13;CD-22-0968.