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DIM-C-pPhOCH3

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Chemical Structure| 33985-68-1 同义名 : C-DIM5
CAS号 : 33985-68-1
货号 : A189636
分子式 : C24H20N2O
纯度 : 99%+
分子量 : 352.428
MDL号 : MFCD01217840
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(99.31 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nerve growth factor-induced Bα (Nur77) is an orphan nuclear receptor overexpressed in colon tumors. DIM-C-pPhOCH3 is a Nur77 agonist. It inhibited RKO cell growth at 24-, 48-, and 72-h post-treatment at a concentration of 10μmol/L. PARP cleavage was observed in RKO cells treated with 12.5μmol/L DIM-C-pPhOCH3 for 48 hours. Treatment with 12.5μmol/L DIM-C-pPhOCH3 for 48 hours also induced the expression of TRAIL protein in RKO cells. DIM-C-pPhOCH3 at a concentration of 12.5 μmol/L also induced the gene expression of PDCD1, CSE, and ATF3 in RKO cells 6 hours after exposure. DIM-C-pPhOCH3 treatment at 12.5 μmol/L induced apoptosis (PARP cleavage) in RKO, SW480, HCT-116, and HT-29 cells at 24-h post-treatment but not in HCT-15 cells. In athymic nude mice bearing RKO cell xenografts, oral administration of DIM-C-pPhOCH3 at a dosage of 25 mg/kg/d for 21 days significantly inhibited tumor growth compared with corn oil-treated controls[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.37mL

5.67mL

2.84mL
参考文献

[2]Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83.