All-trans-retinal
产品说明书
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同义名 : | 视黄醛 ;trans-Retinal;Retinaldehyde;NSC 626581;NSC 122757;Retinal;Retinene;Vitamin A aldehyde |
| CAS号 : | 116-31-4 | |
| 货号 : | A188899 | |
| 分子式 : | C20H28O | |
| 纯度 : | 97% | |
| 分子量 : | 284.436 | |
| MDL号 : | MFCD00001550 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(369.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | All-trans-retinal (atRAL) is a one of the major vitamin A metabolites in the retina. In physiological conditions, all-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal. Necrosis was demonstrated not to be the main pathway in atRAL mediated cell death. Bcl-2-interacting mediator and Bcl-2 expression levels were not altered by atRAL in vitro. atRAL-induced oxidative stress results in DNA damage leading to the activation of Bax by phosphorylated p53[1]. Phosphorylation of JNK (c-Jun N-terminal kinase) in atRAL-loaded photoreceptor cells induced the appearance of γH2AX, a sensitive marker for DNA damage, and was also associated with apoptosis onset[2].Photoactivated rhodopsin releases all-trans-RAL, which is subsequently transported by ATP-binding cassette transporter 4 and reduced to all-trans-retinol by all-trans-retinol dehydrogenases located in photoreceptor cells. Any interruptions in the clearing of all-trans-RAL in the photoreceptors can cause an accumulation of this reactive aldehyde and its toxic condensation products[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.52mL 0.70mL 0.35mL |
17.58mL 3.52mL 1.76mL |
35.16mL 7.03mL 3.52mL |
| 参考文献 |
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