Indole-3-carboxylic acid
产品说明书
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同义名 : | 3-吲哚甲酸 ;I3CA;ICOOH;β-Indolylcarboxylic Acid;Indole-β-carboxylic Acid |
| CAS号 : | 771-50-6 | |
| 货号 : | A188858 | |
| 分子式 : | C9H7NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 161.16 | |
| MDL号 : | MFCD00005624 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(651.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases[2]. A novel series of 1H-indole-3-carboxylic acid pyridine-3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT(2C) receptor. Among them, 1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-yloxy)-pyridin-3-yl]-amide (15k) exhibits the highest affinity (IC50=0.5 nM) with an excellent selectivity (>2000 times) over other serotonin (5-HT(1A), 5-HT(2A), and 5-HT(6)) and dopamine (D(2)-D(4)) receptors[3]. After oral administration to mice, I3C (Indole-3-carbinol), in addition to its acid condensation products, is absorbed from the gut and distributed systemically into a number of well-perfused tissues, thus allowing the possibility for some pharmacological activity of the parent compound in vivo[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.21mL 1.24mL 0.62mL |
31.03mL 6.21mL 3.10mL |
62.05mL 12.41mL 6.21mL |
| 参考文献 |
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