Meropenem Trihydrate

产品说明书

Print
Chemical Structure| 119478-56-7 同义名 : 美罗培南三水合物 ;SM 7338 trihydrate;Meropenem (hydrate);SM-7338;ICI 194660
CAS号 : 119478-56-7
货号 : A188476
分子式 : C17H31N3O8S
纯度 : 97%
分子量 : 437.51
MDL号 : MFCD08600005
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(239.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(27.43 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Meropenem Trihydrate is a novel carbapenem antibiotic for injection[3]. Meropenem, like imipenem and various experimental penems, may overcome the resistance problems presented by Class I beta-lactamases[4]. Antibacterial drugs significantly inhibit hPON1 activity with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro[5]. Meropenem can cause severe liver injury and that early recognition of drug-induced liver injury is important[6]. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Radiostelization is a promising, alternative method for obtaining sterile meropenem[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01551394 Sepsis Phase 3 Completed - Italy ... 展开 >> Ursula TRAFOJER Padova, Italy, 35128 收起 <<
NCT01554124 Meningitis Phase 1 Phase 2 Completed - United Kingdom ... 展开 >> HEATH, Paul London, Cranmer Terrace, United Kingdom, SW17 ORE 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.43mL

2.29mL

1.14mL

22.86mL

4.57mL

2.29mL
参考文献

[1]Slaney L, Chubb H, et al., In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother, 1989. 24 Suppl A: p. 183-6.

[2]Voutsinas D, Mavroudis T, et al. In-vitro activity of meropenem, a new carbapenem, against multiresistant Pseudomonas aeruginosa compared with that of other antipseudomonal antimicrobials. J Antimicrob Chemother. 1989 Sep;24 Suppl A:143-7.

[3]Takeuchi Y, Takebayashi Y, Sunagawa M, Isobe Y, Hamazume Y, Uemura A, Noguchi T. The stability of a novel carbapenem antibiotic, meropenem (SM-7338), in a solid state formulation for injection. Chem Pharm Bull (Tokyo). 1993 Nov;41(11):1998-2002. doi: 10.1248/cpb.41.1998. PMID: 8293523.

[4]Yang YJ, Livermore DM. Interactions of meropenem with class I chromosomal beta-lactamases. J Antimicrob Chemother. 1989 Sep;24 Suppl A:207-17. doi: 10.1093/jac/24.suppl_a.207. PMID: 2808208.

[5]Söyüt H, Kaya ED, Beydemir S. Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study. Asian Pac J Trop Biomed. 2014 Aug;4(8):603-9. doi: 10.12980/APJTB.4.2014APJTB-2014-0059. PMID: 25183328; PMCID: PMC4037652.

[7]Kilińska K, Cielecka-Piontek J, Skibiński R, Szymanowska D, Miklaszewski A, Bednarski W, Tykarska E, Stasiłowicz A, Zalewski P. The Radiostability of Meropenem Trihydrate in Solid State. Molecules. 2018 Oct 23;23(11):2738. doi: 10.3390/molecules23112738. PMID: 30360551; PMCID: PMC6278425.