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EG00229

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Chemical Structure| 1210945-69-9 同义名 : EG 00229 (trifluoroacetate salt)
CAS号 : 1210945-69-9
货号 : A187656
分子式 : C19H20F3N7O7S3
纯度 : 99%+
分子量 : 611.595
MDL号 : MFCD28167995
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(65.4 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 EG00229 is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 μM(125I-VEGF binding to PAE/NRP1 cells).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.18mL

1.64mL

0.82mL

16.35mL

3.27mL

1.64mL
参考文献

[1]Nissen JC, Selwood DL, et al. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402.

[2]Jarvis A, Allerston CK, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26.