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Salicylic acid

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Chemical Structure| 69-72-7 同义名 : 水杨酸 ;2-Hydroxybenzoic acid;NSC 180
CAS号 : 69-72-7
货号 : A187633
分子式 : C7H6O3
纯度 : 98%
分子量 : 138.12
MDL号 : MFCD00002439
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(362 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(7.24 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • COX
描述 Salicylic acid is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/mL) activation. Salicylic acid inhibits prostaglandin E2 release when add together with interleukin 1β for 24 hr with an IC50 value of 5 μg/mL, an effect that is independent of NF-κB activation or COX-2 transcription or translation. Salicylic acid acutely (30 min) also causes a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μM exogenous arachidonic acid. In contrast, when exogenous arachidonic acid is increased to 30 μM, salicylic acid is a very weak inhibitor of COX-2 activity with an IC50 of >100 μg/mL. Salicylic acid causes a concentration-dependent inhibition of COX-2 activity in the absence of added arachidonic acid or in the presence of 1 or 10 μM exogenous substrate with an apparent IC50 value of approximately 5 μg/mL. However, when the same experiments are performed using 30 μM arachidonic acid, salicylic acid is an ineffective inhibitor of COX-2 activity, with an apparent IC50 value of more than 100 μg/mL, and achieves a maximal inhibition of less than 50%[3]. Salicylic acid (SA) is a key plant hormone that mediates host responses against microbial pathogens[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.24mL

1.45mL

0.72mL

36.20mL

7.24mL

3.62mL

72.40mL

14.48mL

7.24mL
参考文献

[1]Ma C, Xie D, et al. Protective effect of salicylic acid on Hg(0) intoxication in mice. Inhal Toxicol. 2013 Jun;25(7):398-404.

[2]Mitchell JA, Saunders M, et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51(6):907-12.

[3]Mitchell JA, Saunders M, Barnes PJ, Newton R, Belvisi MG. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997;51(6):907-912

[4]Kumar D. Salicylic acid signaling in disease resistance. Plant Sci. 2014;228:127-134