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DC-TEADin02

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Chemical Structure| 2380228-45-3 同义名 : -
CAS号 : 2380228-45-3
货号 : A1868736
分子式 : C19H17NO2S
纯度 : 98%
分子量 : 323.409
MDL号 : MFCD34676430
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(324.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DC-TEADin02 is a potent inhibitor of TEAD autopalmitoylation, exhibiting an IC50 value of 197 nM for inhibiting TEAD autopalmitoylation. It is applicable for studies on development, regeneration, and tissue homeostasis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.46mL

3.09mL

1.55mL

30.92mL

6.18mL

3.09mL
参考文献

[1]Wenchao Lu, et al. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. Eur J Med Chem. 2019 Dec 15;184:111767.