产品说明书
Galangin
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同义名 : | Norizalpinin;3,5,7-Trihydroxyflavone;NSC 407229 |
| CAS号 : | 548-83-4 | |
| 货号 : | A186535 | |
| 分子式 : | C15H10O5 | |
| 纯度 : | 98+% | |
| 分子量 : | 270.237 | |
| MDL号 : | MFCD00006833 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(444.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Galangin shows inhibition of CYP1A1 (cytochrome P450 1A1) activity. Galangin inhibited the catabolic breakdown of DMBA (7,12-dimethylbenz[a]anthracene), as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibited the formation of DMBA-DNA adducts, and prevented DMBA-induced inhibition of cell growth. Moreover, galangin is a potent inhibitor of DMBA metabolism and an agonist/antagonist of the AhR[3]. Galangin treatment inhibited cell proliferation and induced autophagy (130 μ mol/l) and apoptosis (370 μ mol/l). The galangin-induced autophagy was attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level[4]. Galangin prevents HCC through multiple anti-cancer mechanisms, anti-genotoxic activity against environmental and dietary carcinogens; anti-proliferative effects through reversal of the Warburg effect in HCC(Hepatocellular carcinoma); arrest of the cell cycle in the G0/G1 phase; induction of apoptosis via stimulation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and the mitochondrial-dependent apoptosis pathway; induction of autophagy; and inhibition of angiogenesis, metastasis, and multidrug resistance (MDR) [5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.70mL 0.74mL 0.37mL |
18.50mL 3.70mL 1.85mL |
37.00mL 7.40mL 3.70mL |
| 参考文献 |
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