Levetiracetam

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Chemical Structure| 102767-28-2 同义名 : UCB L059;SIB-S1;Levetiracetam, Keppra, Etiracetam, UCB 6474
CAS号 : 102767-28-2
货号 : A185961
分子式 : C8H14N2O2
纯度 : 98%
分子量 : 170.21
MDL号 : MFCD03265610
存储条件：

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 90 mg/mL(528.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 85 mg/mL(499.39 mM)
动物实验配方：
生物活性
靶点

  • Calcium Channel
描述 Levetiracetam is an anticonvulsant with antihyperalgesic efficacy in inflammatory pain. It binds the synaptic vesicle protein SV2A (pIC50 = 5.7), presumably altering vesicle exocytosis.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01392768 Epilepsy Part... 展开 >>ial Seizures 收起 << Phase 3 Completed - -
NCT00413296 Post-Traumatic Stress Disorder Phase 2 Phase 3 Completed - United States, North Carolina ... 展开 >> Duke University Medical Center Durham, North Carolina, United States, 27705 收起 <<
NCT00826865 Seizures Not Applicable Completed - United States, Arizona ... 展开 >> MDS Pharma Services Phoenix, Arizona, United States, 85044 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.88mL

1.18mL

0.59mL

29.38mL

5.88mL

2.94mL

58.75mL

11.75mL

5.88mL
参考文献

[1]Rigo JM, Hans G, et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br J Pharmacol. 2002 Jul;136(5):659-72.

[2]Lukyanetz EA, Shkryl VM, Kostyuk PG. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 2002 Jan;43(1):9-18.