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L-Cycloserine

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Chemical Structure| 339-72-0 同义名 : 环丝氨酸 ;(S)-Cycloserine;(S)-4-Amino-3-isoxazolidone;BRN 0080799;L-Oxamicina;Cyclo-L-serine;L-4-amino 3-Isoxazolidinone;(-)-Cycloserine;Levcycloserinum;Levcicloserina;Levcycloserine
CAS号 : 339-72-0
货号 : A185463
分子式 : C3H6N2O2
纯度 : 98%+
分子量 : 102.092
MDL号 : MFCD00064324
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(117.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(117.54 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease[3]. L-cycloserine injected subcutaneously in young mice have shown that cerebroside synthesis is inhibited specifically. It is also resulted in significant reduction in brain cerebroside level with low-dose injection for two month; liver and spleen glucocerebroside levels were also significantly reduced[4]. L-Cycloserine inhibited the activity of gamma-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3-4 hr after injection. L-Cycloserine (10-30 mg/kg, p.o. or i.p.) prevented tonic seizures induced by 3-mercaptopropionic acid (3-MPA) and audiogenic seizures in DBA/2 mice. Similarly, small doses of L-cycloserine reduced the level of cGMP in the cerebellum of rats. Larger doses of L-cycloserine (greater than 30-100 mg/kg) impaired the performance of mice in the rotarod, chimney and horizontal wire tests, and reduced spontaneous locomotor activity of rats[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

9.80mL

1.96mL

0.98mL

48.98mL

9.80mL

4.90mL

97.95mL

19.59mL

9.80mL
参考文献

[1]Cho JY. Effect of L-cycloserine on cellular responses mediated by macrophages and T cells. Biol Pharm Bull. 2007 Nov;30(11):2105-12.

[2]Sundaram KS, Lev M. Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo. J Neurochem. 1984 Feb;42(2):577-81.

[3]Sundaram KS, Lev M. L-cycloserine inhibition of sphingolipid synthesis in the anaerobic bacterium Bacteroides levii. Biochem Biophys Res Commun. 1984 Mar 15;119(2):814-9

[4]Sundaram KS, Lev M. The long-term administration of L-cycloserine to mice: specific reduction of cerebroside level. Neurochem Res. 1989 Mar;14(3):245-8

[5]Polc P, Pieri L, Bonetti EP, Scherschlicht R, Moehler H, Kettler R, Burkard W, Haefely W. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25(4):411-8