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Chitosan

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Chemical Structure| 9012-76-4 同义名 : -
CAS号 : 9012-76-4
货号 : A184597
分子式 : -
纯度 : DAC>95%
分子量 : 0
MDL号 : MFCD00149018
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

0.1 M HCL: 5 mg/mL，配合低频超声，并调节pH至1
动物实验配方：
生物活性
描述 Chitosan is a natural polycationic linear polysaccharide derived from chitin. Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability[3]. Chitosan, a natural macromolecule. Whereas chitosan decreased adhesion of primary melanoma A375 cell line and decreased proliferation of primary melanoma SKMEL28 cell line, it had potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line[4]. Chitosan slowed-down the rate of tumor growth but did not inhibit tumor formation[5]. Chitosan has some apparent treatment effects on rat PCP (Pneumocystis pneumonia) by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL-10 and IFN-γ as well as CD4(+) T-lymphocyte numbers, reducing the CD8(+) T-lymphocyte numbers and the concentration of TNF-α and inducing significant ultrastructural damage to P. carinii[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01246895 - Completed - Canada, Alberta ... 展开 >> University of Calgary Sports Medicine Centre Calgary, Alberta, Canada, T2N 1N4 Canada, British Columbia Simon Fraser Orthopaedic Fund, Royal Columbian Hospital New Westminster, British Columbia, Canada, V3L 3W7 Joint Preservation Centre of British Columbia Vancouver, British Columbia, Canada, V6T 2B5 Canada, Manitoba Pan Am Clinic Winnipeg, Manitoba, Canada, R3M 3E4 Canada, Nova Scotia Orthopaedic and Sport Medicine Clinic of Nova Scotia Halifax, Nova Scotia, Canada, B3H 4M2 Canada, Ontario Oakville Trafalgar Memorial Hospital Oakville, Ontario, Canada, L6J 3L7 Sports Medicine Center, Carleton University Ottawa, Ontario, Canada, K1S 5B6 Sunnybrook Health Sciences Centre, Orthopaedics Research Office Toronto, Ontario, Canada, M4N 3M5 Canada, Quebec Hospital Sacré-Coeur de Montréal Montreal, Quebec, Canada, H4J 1C5 CHA-Pavillon Enfant-Jésus Québec, Quebec, Canada, G1J 1Z4 Hôpital Charles LeMoyne, Unité d'investigation non invasive Québec, Quebec, Canada, J4V 2H1 Spain FREMAP Centro de Prevención y Rehabilitatión Majadahonda, Madrid, Spain Hospital Clinic i Provincial de Barcelona Barcelona, Spain, 08036 Cirugia Ortopedica y Traumatologia, Medicina del Deporte Gijon, Spain Hospital General Universitario Gregorio Marañón Madrid, Spain, 28007 Hospital Universitario La Paz Madrid, Spain 收起 <<
NCT00434538 Diabetic Foot Ulcer Phase 3 Terminated(Due to Sponsor's fi... 展开 >>nancial reasons) 收起 << - Canada, Alberta ... 展开 >> Foothills Medical Center Col Belcher Hospital Calgary, Alberta, Canada, T2N 2T9 Canada, British Columbia Surrey Memorial Hospital Fraser Health Authority Surrey, British Columbia, Canada, V3V 2K1 Canada, Manitoba Infection Control Unit, Infectious Diseases and Medical Microbiology, University of Manitoba Health Sciences Centre Winnipeg, Manitoba, Canada, R3A 1R9 Dermadvance Research Winnipeg, Manitoba, Canada, R3C 1R4 Canada, Newfoundland and Labrador James Paton Memorial Hospital Gander, Newfoundland and Labrador, Canada, A1V 1P7 Canada, Nova Scotia Queen Elizabeth II Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 3A7 Riverside Professional Centre Sydney River, Nova Scotia, Canada, B1S 3N1 Canada, Ontario The Mayer Institute Hamilton, Ontario, Canada, L8R 2R3 Wassay Gezhig Na Nahn Dah We Igamig Kenora, Ontario, Canada, P9N 1Y9 Parkwood Hospital London, Ontario, Canada, N6C 5J1 Dermatology Clinic Mississauga, Ontario, Canada, L4Y1A6 EntraLogix Clinical Group Newmarket, Ontario, Canada, L3Y 2R2 St Michael's Hospital Toronto, Ontario, Canada, M5C 1R8 Dermatology Daycare and Wound Healing Clinic Toronto, Ontario, Canada, M5S 1B5 Canada, Quebec Centre podiatrique Boucherville, Quebec, Canada, J4B 5E4 Clinique de dermatologie Giard & Toscano, 500 Greber #110 Gatineau, Quebec, Canada, J8T 7W3 Centre de Recherche Clinique de Laval Laval, Quebec, Canada, H7T 2P5 CHAU-Hôtel-Dieu de Lévis, Département de médecine de jour- 5ème étage, Clinique des plaies complexes Levis, Quebec, Canada, G6V 3Z1 CHUM - Hotel Dieu Montreal, Quebec, Canada, H2W 1T8 St-Jerome Medical Research Inc. St-Jerome, Quebec, Canada, J7Z 5T3 收起 <<
NCT00314236 - Completed - -
参考文献

[1]Cheung RC, Ng TB, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86.

[2]Yeh MY, Wu MF, et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res. 2013 Nov;33(11):4867-73.

[3]Cheung RC, Ng TB, Wong JH, Chan WY. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015;13(8):5156-5186. Published 2015 Aug 14

[4]Gibot L, Chabaud S, Bouhout S, Bolduc S, Auger FA, Moulin VJ. Anticancer properties of chitosan on human melanoma are cell line dependent. Int J Biol Macromol. 2015;72:370-379

[5]Yeh MY, Wu MF, Shang HS, et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res. 2013;33(11):4867-4873

[6]Liu AB, Pu Y, Zheng YQ, Cai H, Ye B. Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat. Parasite Immunol. 2014;36(7):292-302