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L-Ascorbic Acid

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Chemical Structure| 50-81-7 同义名 : L-抗坏血酸;维生素C ;L-Ascorbate;Vitamin C;Ascorbic acid, L-Ascorbic acid;NSC 218455;NSC 33832;Ascorbate
CAS号 : 50-81-7
货号 : A182821
分子式 : C6H8O6
纯度 : 98%
分子量 : 176.12
MDL号 : MFCD00064328
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(596.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(567.79 mM)
动物实验配方：
生物活性
描述 L-Ascorbic Acid, also named as Vitamin C, is a water-soluble compound, widely existing in many vegetables and fruits. In vivo studies, L-ascorbic acid could promote the proliferation of human epithelial HaCaT cells [1] . Besides this, it was found that L-ascorbic acid could also suppress the leukemic cell colony in simultaneous cultures, even at the concentration of 0.1 mM [2] . In vivo studies, L-ascorbic acid has the ability of protecting lead toxicated rats against anemia [3] . In addition, it was observed that L-ascorbic acid contributed to the improvement of examined electrophysiological parameters in rats [4] .
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02553551 Chronic Cholecystitis ... 展开 >> Cholelithiasis 收起 << Not Applicable Unknown September 2017 Korea, Republic of ... 展开 >> Department of HBP Surgery, Seoul St. Mary's hospital Recruiting Seoul, Seocho-gu, Banopo-dong, Korea, Republic of, 137-701 Contact: Taeho Hong    +82-2-2258-6108    gshth@catholic.ac.kr 收起 <<
NCT01080352 Prostatic Neoplasms Phase 2 Completed - Denmark ... 展开 >> Departmen of Urology, Copenhagen University Hospital at Herlev Herlev, DK, Denmark, 2730 收起 <<
NCT02186158 Pneumonia With Hospitalized El... 展开 >>derly Patient 收起 << Phase 2 Completed - France ... 展开 >> CHU de Bordeaux, Hôpital Saint André Bordeaux, France, 33000 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.39mL

5.68mL

2.84mL

56.78mL

11.36mL

5.68mL
参考文献

[1]Lam PL, Kok SH, et al. Microencapsulation-protected l-ascorbic acid for the application of human epithelial HaCaT cell proliferation. J Microencapsul. 2014;31(8):754-8.

[2]Park CH, Amare M, et al. Growth suppression of human leukemic cells in vitro by L-ascorbic acid. Cancer Res. 1980;40(4):1062-5.

[3]Rudra PD, Chatterjee J, Chatterjee GC. Influence of lead administration on L-ascorbic acid metabolism in rats: effect of L-ascorbic acid supplementation. Int J Vitam Nutr Res. 1975;45(4):429-37.

[4]Kosik-Bogacka DI, Baranowska-Bosiacka I, et al. The effect of L-ascorbic acid and/or tocopherol supplementation on electrophysiological parameters of the colon of rats chronically exposed to lead. Med Sci Monit. 2011;17(1):BR16-26.