(S)-(+)-Ibuprofen

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Chemical Structure| 51146-56-6 同义名 : 左旋布洛芬 ;Dexibuprofen;(S)-Ibuprofen;(+)-Ibuprofen
CAS号 : 51146-56-6
货号 : A182774
分子式 : C13H18O2
纯度 : 98%
分子量 : 206.281
MDL号 : -
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(509.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(4.85 mM)

无水乙醇: 100 mg/mL(484.78 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 (S)-(+)-Ibuprofen, the S(+)-enantiomer of ibuprofen, is an effective inhibitor of both COX-1 and COX-2 enzymes, with IC50 values of 2.1 μM and 1.6 μM, respectively. It is recognized for its analgesic, anti-inflammatory, anticancer, and antipyretic properties[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.48mL

24.24mL

4.85mL

2.42mL

48.48mL

9.70mL

4.85mL
参考文献

[1]Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.

[2]Astrid Janssen, et al. Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. Eur J Pharmacol. 2006 Jul 1;540(1-3):24-33.

[3]N Scheuren, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.