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ICA-121431

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Chemical Structure| 313254-51-2 同义名 : -
CAS号 : 313254-51-2
货号 : A181030
分子式 : C23H19N3O3S2
纯度 : 99%+
分子量 : 449.545
MDL号 : MFCD00992334
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(100.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ICA-121431 is a nanomolar potent, broad-spectrum blocker of voltage-gated sodium channels (Nav), exhibiting particularly strong selectivity for the human Nav1.1 and Nav1.3 subtypes, with IC50 values of 13 nM and 23 nM, respectively[1]. For wild type human Nav channels, it shows IC50 values of 0.013 µM for hNav1.3, over 30 µM for hNav1.5, and 12 µM for hNav1.7, demonstrating its selective blocking capability[1]. ICA-121431 is against hNav channels with point mutations,showshNav1.3/hNav1.5 S1-S4, hNav1.3/hNav1.5 S3-S4, hNav1.3/hNav1.5 S5-S6, hNav1.3/hNav1.7 S1, hNav1.3/hNav1.7 S2, hNav1.3/hNav1.7 S3-S4, and hNav1.3/hNav1.7 S5-S6 with IC50 values of 0.083 µM, 1.2 µM, 11 µM, 2.0 µM, 0.045 µM, 0.030 µM, 0.30 µM, 1.0 µM, and 0.024 µM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.24mL

4.45mL

2.22mL
参考文献

[1]McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.