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Emodin

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Chemical Structure| 518-82-1 同义名 : Frangula emodin;Archin;rheum emodin, 3-methyl-1,6,8-trihydroxyanthraquinone, Schuttgelb, and Persian Berry Lake.;HSDB 7093;Emodol;Schuttgelb;NSC 622947;NSC 408120;Frangulic Acid
CAS号 : 518-82-1
货号 : A178654
分子式 : C15H10O5
纯度 : 98%
分子量 : 270.237
MDL号 : MFCD00001207
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(14.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

8% DMSO+75% PEG 300+8% Tween 80+water 12 mg/mL

生物活性
靶点

  • Dehydrogenase
描述 Among various Ser/Thr protein kinases, CKII plays a potential role in the processes of cell proliferation, transformation, and differentiation. In addition, abolition of CKII activity causes cell death in yeast, whereas overexpression of the CKII α-subunit gene in animal cells causes the cells to become oncogenic. Emodin, an anthraquinone derivative, selectively and competitively inhibits CKII with IC50 of 2 μM and Ki of 7.2 μM[5]. HepG2 cells treated with 25 μM emodin for 48 h displayed apoptotic morphological changes[6]. Emodin killed T24 and J82 cells in a dose-dependent manner after 24 h treatment. It also killed T24 at concentration of 20 μM and J82 cells at concentration of 15 μM in a time-dependent manner. Mice treated with emodin and cisplatin had significantly smaller tumors than those from the other groups indicating emodin/cisplatin co-treatment can significantly suppress tumor growth in vivo[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Feng Y, Huang SL, et al, Leng Y. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161(1):113-26.

[2]Yim H, Lee YH, et al. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13.

[3]Liu JX, Zhang JH, et al. Emodin induces Panc-1 cell apoptosis via declining the mitochondrial membrane potential. Oncol Rep. 2012 Dec;28(6):1991-6.

[4]Song P, Kim JH, et al. Emodin regulates glucose utilization by activating AMP-activated protein kinase. J Biol Chem. 2013 Feb 22;288(8):5732-42.

[5]Tzeng TF, Lu HJ, et al. Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats. Evid Based Complement Alternat Med. 2012;2012:781812.

[6]Li RR, Liu XF, et al. Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. Molecules. 2019 May 17;24(10). pii: E1898.

[7]Yim H, Lee YH, Lee CH, Lee SK. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13. doi: 10.1055/s-1999-13953. PMID: 10083837.

[8]Xing JY, Song GP, Deng JP, Jiang LZ, Xiong P, Yang BJ, Liu SS. Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro. PLoS One. 2015 Dec 18;10(12):e0144781. doi: 10.1371/journal.pone.0144781. PMID: 26682731; PMCID: PMC4684281.

[9]Li X, Wang H, Wang J, Chen Y, Yin X, Shi G, Li H, Hu Z, Liang X. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. BMC Cancer. 2016 Aug 2;16:578. doi: 10.1186/s12885-016-2640-3. PMID: 27485374; PMCID: PMC4971704.