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5-Iodotubercidin

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Chemical Structure| 24386-93-4 同义名 : 5-碘代杀结核菌素 ;NSC 113939;5-ITu;Itu
CAS号 : 24386-93-4
货号 : A177991
分子式 : C11H13IN4O4
纯度 : 98%
分子量 : 392.15
MDL号 : -
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(63.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin facilitates glycogen synthesis in isolated hepatocytes by deactivating phosphorylase and activating glycogen synthase. Furthermore, 5-Iodotubercidin obstructs the activity of several kinases including CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin[1].[2].[3].
作用机制 5-iodotubercidin increases the release of adenosine from hypoxic/hypoglycemic hippocampal slices[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.26mL

12.75mL

2.55mL

1.27mL

25.50mL

5.10mL

2.55mL
参考文献

[1]Massillon D, et al. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 (Pt 1):123-8.

[2]Ugarkar BG, et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43(15):2883-93.

[3]García-Villafranca J, et al. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000.

[4]De Antoni A, et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199(2):269-84.