Dehydroacetic acid

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Chemical Structure| 520-45-6 同义名 : Biocide 470F;Methylacetopyronone;NSC 139150
CAS号 : 520-45-6
货号 : A177106
分子式 : C8H8O4
纯度 : 98%
分子量 : 168.147
MDL号 : MFCD00066709
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(297.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid from N-hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were synthesised in order to improve the antibacterial activity of dehydroacetic acid[3]. Analogues of dehydroacetic acid as selective and potent agonists of an ectopic odorant receptor through a combination of hydrophilic and hydrophobic interactions[4]. Moreover, dehydroacetic acid was effective both in controlling growth and guaiacol formation by A. acidoterrestris. Through the addition of 270 mg/L dehydroacetic acid, the A. acidoterrestris counts were reduced by 3.43 log colony forming unit (CFU)/mL, and no guaiacol was detected after 14 days of storage[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02177383 Oxidative Stress ... 展开 >> Exercise Training Season Antioxidant Capabilities Athletic Performance 收起 << Not Applicable Completed - Spain ... 展开 >> University of Balearic Islands Palma de Mallorca, Balearic Islands, Spain, 07122 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.95mL

1.19mL

0.59mL

29.74mL

5.95mL

2.97mL

59.47mL

11.89mL

5.95mL
参考文献

[1]Manku GS, Sarpal PD. Dehydroacetic acid as a reagent for the separation and gravimetric determination of copper(II), aluminium and beryllium. Talanta. 1971 Oct;18(10):1079-82.

[2]Ukita T, Ejima A. [Mode of antibacterial activity of 3-acetyl-4-hydroxycoumarin and dehydroacetic acid. I] . Yakugaku Zasshi. 1962 Dec;82:1625-30. Japanese.

[3]Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S. Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8.

[4]Park BB, Lee N, Kim Y, Jae Y, Choi S, Kang N, Hong YR, Ok K, Cho J, Jeon YH, Lee EH, Byun Y, Koo J. Analogues of Dehydroacetic Acid as Selective and Potent Agonists of an Ectopic Odorant Receptor through a Combination of Hydrophilic and Hydrophobic Interactions. ChemMedChem. 2017 Apr 6;12(7):477-482.

[5]Cai R, Yuan Y, Wang Z, Guo C, Liu B, Pan C, Liu L, Yue T. Effects of preservatives on Alicyclobacillus acidoterrestris growth and guaiacol production. Int J Food Microbiol. 2015 Dec 2;214:145-150.