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Aminomalonic acid

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Chemical Structure| 1068-84-4 同义名 : Aminomalonate;Aminopropanedioic acid
CAS号 : 1068-84-4
货号 : A176423
分子式 : C3H5NO4
纯度 : 97%
分子量 : 119.076
MDL号 : MFCD00673796
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 8 mg/mL(67.18 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Aminomalonic acid (Ama) has been isolated from proteins of Escherichia coli and human atherosclerotic plaque[4]. Aminomalonic acid is a strong in vitro inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR and from mouse pancreas; the agent is formally competitive with L-aspartic acid (Ki = 0.0023 M and 0.0015 M for the tumoral and pancreatic enzymes, respectively). In vivo, aminomalonamide failed to inhibit tumoral L-asparagine synthetase at any time period up to 24 h after its oral or intraperitoneal administration[5]. Aminomalonic acid, guanidinosuccinic acid, and glycerol emerge as potential plasma biomarkers of large aneurysm[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.40mL

1.68mL

0.84mL

41.99mL

8.40mL

4.20mL

83.98mL

16.80mL

8.40mL
参考文献

[1]Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5.

[2]Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47.

[3]Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864.

[4]Van Buskirk JJ, Kirsch WM, Kleyer DL, Barkley RM, Koch TH. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5

[5]Milman HA, Muth R, Cooney DA. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47

[6]Qureshi MI, Greco M, Vorkas PA, Holmes E, Davies AH. Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research. J Proteome Res. 2017 Jul 7;16(7):2325-2332