Levamisole
产品说明书
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同义名 : | 左旋咪唑碱 ;(-)-Tetramisole |
| CAS号 : | 14769-73-4 | |
| 货号 : | A176170 | |
| 分子式 : | C11H12N2S | |
| 纯度 : | 97% | |
| 分子量 : | 204.291 | |
| MDL号 : | MFCD00792481 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(513.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Levamisole is an anthelmintic agent with immunomodulatory effects[1]. Treatment of human dendritic cells with 1 μM levamisole significantly promoted the secretion of IL-12 p40 and IL-10 secretion compared to the control group. Levamisole at 1 μM also further enhanced lipopolysaccharide (10 ng/mL)-induced production of IL-12 p40 and IL-10 in human dendritic cells. Levamisole-treated dendritic enhanced T cell activation towards type 1 cytokine balance. The NF-κB and JNK pathways were involved in levamisole-induced secretion of IL-12 p40 in dendritic cells[2]. In mice infected with 1,000 infective T canis larvae, subcutaneous administration of levamisole hydrochloride at a dose of 12 mg/kg/day from days 15 to 28 of infection decreased the infection in all organs[3]. | ||
| 作用机制 | Levamisole exerts its immunomodulatory effects through cholinergic activity on T lymphocytes, resulting in an increase in the level of cyclic guanosine monophosphate in lymphocytes[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.89mL 0.98mL 0.49mL |
24.47mL 4.89mL 2.45mL |
48.95mL 9.79mL 4.89mL |
| 参考文献 |
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