5'-Guanylic acid
产品说明书
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同义名 : | 5'-GMP;5'-guanosine monophosphate |
| CAS号 : | 85-32-5 | |
| 货号 : | A175940 | |
| 分子式 : | C10H14N5O8P | |
| 纯度 : | 97% | |
| 分子量 : | 363.221 | |
| MDL号 : | MFCD00057066 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3个月-80°C:12个月 |
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| 溶解度 : |
H2O: 85 mg/mL(234.02 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 5'-GMP is a nucleotide involving RNA synthesis. It can be used to study modulation of glutamatergic neurotransmission. guanosine-5'-monophosphate (GMP)(5'-GMP) or guanosine (GUO), promote the reorganization of extracellular matrix proteins in astrocytes, and increase the number of neurons in a neuron-astrocyte co-culture protocol[1]. Guanosine-5'-monophosphate (GMP) is shown to be neuroprotective against glutamate- or oxygen/glucose deprivation-induced neurotoxicity and also against NMDA-induced apoptosis in hippocampal slices. High extracellular GMP concentrations (5mM) reduced cell viability in hippocampal brain slices. GMP (5mM) induced a decrease in glutamate uptake into hippocampal slices, which was reversed by dl-TBOA. GMP-induced hippocampal cell damage involves activation of ionotropic glutamate receptors and inhibition of glutamate transporters activity[2]. The administration of 25 and 50mg/kg GMP was able to promote anxiolytic-like behavior, in the light/dark and elevated plus-maze task, similar to diazepam effect. Acute administration of GMP was able to decrease the levels of anxiety in classical behavioral tasks[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.75mL 0.55mL 0.28mL |
13.77mL 2.75mL 1.38mL |
27.53mL 5.51mL 2.75mL |
| 参考文献 |
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