Fursultiamine

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Chemical Structure| 804-30-8 同义名 : Thiamine Tetrahydrofurfuryl Disulfide;TTFD;Tetrahydrofurfuryl thiamine disulfide;EINECS 212-357-1;Linamin;Judolor;Fursultiamin
CAS号 : 804-30-8
货号 : A175577
分子式 : C17H26N4O3S2
纯度 : 98%
分子量 : 398.543
MDL号 : MFCD00867383
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 100 mg/mL(250.91 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 6.5 mg/mL(16.31 mM)
动物实验配方：
生物活性
描述 Fursultiamine, also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a synthetic counterpart of allithiamine, a substance naturally found in garlic. The administration of TTFD (50 mg/kg, i.p.) for 5 days significantly increased the swimming duration of rats in weight-loaded forced swimming test (1.7-fold compared to the controls). TTFD treatment also elevated the levels of thiamine (4.0-fold vs. control), thiamine monophosphate (1.6-fold vs. control) and thiamine pyrophosphate (2.3-fold vs. control) in the skeletal muscle of rats. Forced swimming resulted in a decreased ATP level in the gastrocnemius of vehicle-treated rats (27% reduction compared to non-swimming group), but led to a significantly smaller decrease in those of rats treated with TTFD for 5 days (14% reduction compared to non-swimming group)[3].
作用机制 TTFD accelerates the re-synthesis of ATP by accumulating high levels of thiamine pyrophosphate and stimulating glycogenolysis in the skeletal muscle during exercise.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02423811 Cancer Stem Cell Phase 2 Unknown - Taiwan ... 展开 >> National Cheng Kung University Hospital Recruiting Tainan, Taiwan, 704 Contact: Forn-Chia Lin, M.D., Ph.D.    886-6-2353535 ext 2463    fornchia@mail.ncku.edu.tw 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.09mL

5.02mL

2.51mL
参考文献

[1]Kobayashi T, Notoya K, et al. Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. Inflamm Res. 2005 Jun;54(6):249-55.

[2]Bjornberg A, Lowhagen GB, et al. Skin reactivity in workers with and without itching from occupational exposure to glass fibres. Acta Derm Venereol. 1979;59(1):49-53.

[3]Nozaki S, Mizuma H, Tanaka M, Jin G, Tahara T, Mizuno K, Yamato M, Okuyama K, Eguchi A, Akimoto K, Kitayoshi T, Mochizuki-Oda N, Kataoka Y, Watanabe Y. Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats. Nutr Res. 2009 Dec;29(12):867-72. doi: 10.1016/j.nutres.2009.10.007. PMID: 19963160.