Creatinine

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Chemical Structure| 60-27-5 同义名 : 肌酸酐 ;NSC13123
CAS号 : 60-27-5
货号 : A174549
分子式 : C4H7N3O
纯度 : 98%
分子量 : 113.118
MDL号 : MFCD00059730
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(17.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(265.21 mM)，配合低频超声助溶
动物实验配方：

PO 0.5% CMC-Na 80 mg/mL clear

生物活性
描述 Creatinine (NSC13123) is a byproduct of creatine phosphate breakdown in muscle, typically produced at a relatively stable rate by the body[1]. The measurement of creatinine levels in blood and urine is essential for calculating creatinine clearance (CrCl), which is indicative of the glomerular filtration rate (GFR), a crucial indicator of kidney function[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01756703 Diabetic Nephropathy Phase 2 Completed - -
NCT01113801 Diabetic Kidney Disease ... 展开 >> Diabetic Nephropathy Diabetic Glomerulosclerosis 收起 << Phase 2 Terminated(Interim Assessment ... 展开 >>Lack of Efficacy) 收起 << - -
NCT02955979 - Recruiting December 2019 France ... 展开 >> CHU de Lyon Recruiting Lyon, France, 69310 Contact: Etienne Javouhey, MD PhD    (0)472129735 ext +33    etienne.javouhey@chu-lyon.fr    Principal Investigator: Etienne Javouhey, MD PhD          Sub-Investigator: Yves Gillet, MD PhD          Chu Saint-Etienne Recruiting Saint Etienne, France, 42055 Contact: Olivier MORY, MD    (0)477828632 ext +33    olivier.mory@chu-st-etienne.fr    Principal Investigator: Olivier MORY, MD          Sub-Investigator: Aymeric CANTAIS, MD          Sub-Investigator: Hugues PATURAL, MD PhD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.84mL

1.77mL

0.88mL

44.20mL

8.84mL

4.42mL

88.40mL

17.68mL

8.84mL
参考文献

[1]Allen, P.J., Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value. Neurosci Biobehav Rev, 2012. 36(5): p. 1442-62.

[2]Levey, A.S., et al., Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med, 2006. 145(4): p. 247-54.