产品说明书
Dipsacoside B
 |
同义名 : | 川续断皂苷 B |
| CAS号 : | 33289-85-9 | |
| 货号 : | A172469 | |
| 分子式 : | C53H86O22 | |
| 纯度 : | 95% | |
| 分子量 : | 1075.237 | |
| MDL号 : | MFCD03424249 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(97.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dipsacoside B is a major bioactive saponin isolated and purified from the flowerbuds of Lonicera confusa DC. DB (Dipsacoside B) alleviated hepatotoxicity caused by APAP (acetaminophen) at least in part via Neu1 inhibition, Akt/mTOR pathway is involved in the detoxification effect of DB on acetaminophen-induced hepatotoxicity[3]. Dipsacoside B is a major bioactive saponin, which can be used as a marker. A liquid chromatography-electrospray ionization-mass spectrometry method has been developed and validated for identification and quantification of four major bioactive saponins in rat plasma after oral administration of extraction of saponins from Flos Lonicerae, i.e., Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B. The retention time of Macranthoidin B, Macranthoidin A, Dipsacoside B, Macranthoside B and IS are 10.65, 12.11, 13.81, 23.31 and 5.47 min, respectively[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
0.93mL 0.19mL 0.09mL |
4.65mL 0.93mL 0.47mL |
9.30mL 1.86mL 0.93mL |
| 参考文献 |
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