Tylosin

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Chemical Structure| 1401-69-0 同义名 : Tylosin A;Fradizine;Tylosine;Tylocine
CAS号 : 1401-69-0
货号 : A172256
分子式 : C46H77NO17
纯度 : Tylosin A>=80%, Tylosin A+B+C+D>=95%, active unit >= 900u/mg
分子量 : 916.1
MDL号 : MFCD09881413
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(114.62 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tylosin, an antibiotic used for maintaining livestock health, is a macrolide structurally similar to a number of important, often prescribed human antibiotics[3]. Tylosin has antibacterial activity against S.suis CVCC606 in Mueller Hinton (MH) broth and serum. The minimum inhibitory concentrations (MIC) were 0.25 μg/mL, and the minimal bactericidal concentrations (MBC) were 1 μg/mL in MH (Mueller Hinton) broth and serum. A dosage regimen of 5.32 - 19.50 mg/kg b.w. every 24 h should be sufficient for tylosin against S.suis in pigs[4]. Moreover, Tylosin causes fecal dysbiosis in healthy dogs with corresponding shifts in fecal UBAs (unconjugated bile acids). Changes did not uniformly resolve after discontinuation of tylosin[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.09mL

0.22mL

0.11mL

5.46mL

1.09mL

0.55mL

10.92mL

2.18mL

1.09mL
参考文献

[1]Entorf M, Feßler AT, et al. Tylosin susceptibility of Staphylococci from bovine mastitis. Vet Microbiol. 2014 Jul 16;171(3-4):368-73.

[2]Pilcher CM, Arentson R, et al. Impact of tylosin phosphate and distillers dried grains with solubles on energy and nutrient digestibility and flow through the gastrointestinal tract in growing pigs. J Anim Sci. 2013 Dec;91(12):5687-95.

[3]Stromer BS, Woodbury B, Williams CF. Tylosin sorption to diatomaceous earth described by Langmuir isotherm and Freundlich isotherm models. Chemosphere. 2018; 193: 912–920

[4]Huang L, Zhang H, Li M, Ahmad I, Wang Y, Yuan Z. Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs. BMC Vet Res. 2018;14(1):319. Published 2018 Oct 24

[5]Manchester AC, Webb CB, Blake AB, et al. Long-term impact of tylosin on fecal microbiota and fecal bile acids of healthy dogs. J Vet Intern Med. 2019;33(6):2605–2617