产品说明书

ST-1006

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Chemical Structure| 1196994-11-2 同义名 : -
CAS号 : 1196994-11-2
货号 : A1721503
分子式 : C16H20Cl2N6
纯度 : 99%+
分子量 : 367.276
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(326.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94[1][2].At a concentration of 10 μM, ST-1006 is a potent basophil migration inducer that induces basophil migration[2].At concentrations of 0-100 μM, ST-1006 inhibits FceRI-mediated basophil activation and decreases CD63 and CD203c expression levels on FceRI-activated basophils[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.61mL

2.72mL

1.36mL

27.23mL

5.45mL

2.72mL
参考文献

[1]Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.

[2]Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.