Remodelin HBr
产品说明书
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同义名 : | Remodelin hydrobromide;Remodelin (hydrobromide) |
| CAS号 : | 1622921-15-6 | |
| 货号 : | A171428 | |
| 分子式 : | C15H15BrN4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 363.275 | |
| MDL号 : | MFCD28137688 | |
| 存储条件： |
Pure form Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 45 mg/mL(123.87 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Remodelin is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells.Additionally, Remodelin curtails the development of prostate cancer and hepatocellular carcinoma in xenograft models and prolongs the lifespan in models of Hutchinson-Gilford Progeria Syndrome (HGPS)[1].[2].[3].[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.75mL 0.55mL 0.28mL |
13.76mL 2.75mL 1.38mL |
27.53mL 5.51mL 2.75mL |
| 参考文献 |
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