NLRP3-IN-11
产品说明书
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同义名 : | - |
| CAS号 : | 2769040-91-5 | |
| 货号 : | A1702914 | |
| 分子式 : | C17H17ClN4O2 | |
| 纯度 : | 99% | |
| 分子量 : | 344.796 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(348.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | NLRP3-IN-11 serves as an inhibitor of NLR family pyrin domain containing 3 (NLRP3) proteins, displaying biological activity against NLRP3 with an IC50 value of <0.3 μM. It is applicable for research in inflammatory and degenerative diseases, including NASH, atherosclerosis, cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and various other autoinflammatory diseases [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.90mL 0.58mL 0.29mL |
14.50mL 2.90mL 1.45mL |
29.00mL 5.80mL 2.90mL |
| 参考文献 |
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[1]HY-W048205, et al. Compounds for inhibiting NLRP3 and uses thereof. Patent. US11319319B1. |