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Cynaroside

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Chemical Structure| 5373-11-5 同义名 : 朝蓟糖甙 ;Luteolin 7-glucoside;Luteolin 7-O-β-D-glucoside;Luteolin 7-O-Glucoside;Luteolin 7-β-D-Glucopyranoside;Luteoloside
CAS号 : 5373-11-5
货号 : A170248
分子式 : C21H20O11
纯度 : 99%+
分子量 : 448.377
MDL号 : MFCD06799436
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(189.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cynaroside (luteolin-7-O-glucoside or luteoloside) is a flavonoid that has various pharmacological properties, such as antitumor, anti-inflammatory, and antioxidant activities[3]. Cynaroside exhibited antileishmanial activity in time- and dose-dependent manner with 50% of inhibitory concentration (IC50) value of 49.49 ± 3.515 µM in vitro. Cynaroside may be used alone or in combination with existing drug, miltefosine to control leishmaniasis with less cytotoxicity[4]. The topical application of CYN (Cynaroside) significantly reduces the number of T cells, mast cells and histiocytes in mouse skin with inflammation or atopic dermatitis[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.12mL

22.30mL

4.46mL

2.23mL
参考文献

[1]Palombo R, Savini I, et al. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis. 2016 Aug 18;7(8):e2344.

[2]Samet I, Villareal MO, et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55.

[3]Lee SA, Park BR, Moon SM, Hong JH, Kim DK, Kim CS. Chondroprotective Effect of Cynaroside in IL-1β-Induced Primary Rat Chondrocytes and Organ Explants via NF-κB and MAPK Signaling Inhibition. Oxid Med Cell Longev. 2020 Jan 24;2020:9358080

[4]Tabrez S, Rahman F, Ali R, Alouffi AS, Akand SK, Alshehri BM, Alshammari FA, Alam A, Alaidarous MA, Banawas S, Dukhyil AAB, Rub A. Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response. Biosci Rep. 2021 Jan 29;41(1):BSR20203857

[5]Szekalska M, Sosnowska K, Tomczykowa M, Winnicka K, Kasacka I, Tomczyk M. In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations. Biomed Pharmacother. 2020 Jan;121:109681