产品说明书

Azoramide

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Chemical Structure| 932986-18-0 同义名 : -
CAS号 : 932986-18-0
货号 : A169042
分子式 : C15H17ClN2OS
纯度 : 99%+
分子量 : 308.826
MDL号 : MFCD08009374
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(97.14 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Azoramide, a powerful, orally bioavailable small molecule, functions as a modulator of the unfolded protein response (UPR). It enhances ER protein folding capabilities and increases the capacity of ER chaperones, providing protection against ER stress. Furthermore, azoramide mitigates ER stress induced by PLA2G6 mutations by adjusting the unfolded protein response, boosts CERB signaling to restore mitochondrial function, and prevents apoptosis in dopaminergic (DA) neurons. Its efficacy extends to anti-diabetic activities[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.19mL

3.24mL

1.62mL

32.38mL

6.48mL

3.24mL
参考文献

[1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7(292):292ra98.

[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130.