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Antimalarial agent 14

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Chemical Structure| 1150-59-0 同义名 : -
CAS号 : 1150-59-0
货号 : A1684710
分子式 : C16H10O3
纯度 : 99%+
分子量 : 250.249
MDL号 : MFCD00433849
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(479.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Antimalarial agent 14 is a potent inhibitor of mitochondrial electron transport[1].Antimalarial agent 14 inhibits P. falciparum at concentrations less than 400 μM for 48 h (IC50 = 443 nM) but has limited cytotoxicity to human cells (CC50 = 54.6 ± 0.23 μM). Antimalarial agent 14 inhibits the mitochondrial membrane potential of P. falciparum, with IC50 ΔΨmit of 16 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.00mL

0.80mL

0.40mL

19.98mL

4.00mL

2.00mL

39.96mL

7.99mL

4.00mL
参考文献

[1]Schuck DC, et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10;12:234.