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Sulfosuccinimidyl oleate sodium

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Chemical Structure| 1212012-37-7 同义名 : Sulfo-N-succinimidyl oleate sodium;Sulfosuccinimidyl Oleate (sodium salt);SSO
CAS号 : 1212012-37-7
货号 : A1684359
分子式 : C22H36NNaO7S
纯度 : 99%+
分子量 : 481.579
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(124.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of the respiratory chain of the mitochondria. Sulfosuccinimidyl oleate sodium interacts with the CD36 receptor on the surface of microglia[1][2].Sulfosuccinimidyl oleate sodium did not alter cell viability at concentrations of 20 μM and 50 μM for 24 h. The combination of 100 ng/ml LPS+5 ng/mL IFNγ moderately, but significantly, reduced the viability of BV2 cells, which was prevented by concomitant use of Sulfosuccinimidyl oleate sodium. The addition of Sulfosuccinimidyl oleate sodium to the combination at a concentration of 50 μM for 24 hours of treatment significantly reduced LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells and also prevented LPS/IFNγ-induced up-regulation of p38 phosphorylation.[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.38mL

2.08mL

1.04mL

20.77mL

4.15mL

2.08mL
参考文献

[1]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.

[2]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.