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TC-DAPK 6

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Chemical Structure| 315694-89-4 同义名 : -
CAS号 : 315694-89-4
货号 : A168416
分子式 : C17H12N2O2
纯度 : 98%+
分子量 : 276.289
MDL号 : MFCD07278745
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(65.15 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Death-associated protein kinases (DAPKs) play a central role in programmed cell death such as apoptosis and autophagy and are now emerging as targets for drug discovery in novel therapeutic approaches for ischemic diseases in the brain, heart, kidney, and other organs. TC-DAPK 6 is a potent, selective and ATP-competitive DAPKs inhibitor, acting on DAPK1 and DAPK3 with IC50s of 69 and 225 nM, respectively. In a kinase panel assay, TC-DAPK 6 exhibited much reduced or no activity against a panel of other 48 serine/threonine- or tyrosine-kinases tested to date. TC-DAPK 6 also inhibited P70S6K with an IC50 of 1μM[2].
作用机制 TC-DAPK 6 possesses the additional hydrophobic interaction in the ATP binding cavity of DAPK[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.19mL

7.24mL

3.62mL
参考文献

[1]Okamoto M, Takayama K, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7.

[2]Okamoto M, Takayama K, Shimizu T, Ishida K, Takahashi O, Furuya T. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7