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RP-6685

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Chemical Structure| 2832047-80-8 同义名 : -
CAS号 : 2832047-80-8
货号 : A1682801
分子式 : C22H14F7N5O
纯度 : 99%+
分子量 : 497.368
MDL号 : MFCD34676750
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(211.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RP-6685, characterized by potent, selective, and oral activity as a DNA polymerase theta (Polθ) inhibitor, showcases an IC50 value of 5.8 nM in a PicoGreen assay and demonstrates antitumor efficacy in a mouse tumor xenograft model[1]. Serving as a click chemistry reagent, RP-6685 features an Alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-bearing molecules.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.05mL

2.01mL

1.01mL

20.11mL

4.02mL

2.01mL
参考文献

[1]Bubenik M, et al. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ. J Med Chem. 2022 Sep 20.

[2]Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces hypersecretion. J Clin Invest. 2015 Apr;125(4):1692-702