产品说明书

THAM

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Chemical Structure| 77-86-1 同义名 : 三(羟甲基)氨基甲烷 ;Tris;Tris(hydroxymethyl)aminomethane;NSC 6365;Tromethamine;Trometamol
CAS号 : 77-86-1
货号 : A168222
分子式 : C4H11NO3
纯度 : 98%
分子量 : 121.135
MDL号 : MFCD00004679
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 25 mg/mL(206.38 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(412.76 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 THAM (Tris) is a biologically inert amino alcohol with low toxicity that buffers carbon dioxide and acids both in vitro and in vivo. It is an effective amine compound for pH control within the physiological range[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01023724 Post Operative Anterior Chambe... 展开 >>r Inflammation (Flare) 收起 << Phase 4 Completed - United States, Pennsylvania ... 展开 >> Bucci Laser Vision Institute Wilkes-Barre, Pennsylvania, United States, 18702 收起 <<
NCT01023724 - Completed - -
NCT01596166 Probable Migraine ... 展开 >> Migraine With Aura Migraine Without Aura 收起 << Phase 4 Completed - Canada, Alberta ... 展开 >> Alberta Children's Hospital Calgary, Alberta, Canada, T3B 6A8 Stollery Children's Hospital Edmonton, Alberta, Canada, T6G 2C8 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.25mL

1.65mL

0.83mL

41.27mL

8.25mL

4.13mL

82.55mL

16.51mL

8.25mL

参考文献

[1]Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55(2):191-224.