产品说明书
Tetramisole HCl
 |
同义名 : | DL-Tetramisole Hydrochloride;(±)-Tetramisole hydrochloride;R-829;Tetramisole hydrochloride |
| CAS号 : | 5086-74-8 | |
| 货号 : | A167438 | |
| 分子式 : | C11H13ClN2S | |
| 纯度 : | 98% | |
| 分子量 : | 240.752 | |
| MDL号 : | MFCD00005536 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 9 mg/mL(37.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(415.36 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. Tetramisole, a well documented TNAP (tissue non-specific alkaline phosphatase) inhibitor, to block TNAP activity. Tetramisole reduced neuronal response amplitude in a dose-dependent manner. Tetramisole also decreased axonal conduction velocity. The decrease of axonal conduction velocity and preliminary intracellular data suggest that tetramisole blocks voltage-dependent sodium channels[3]. Nervous involvement in the acute toxicity of tetramisole. Subcutaneous injection of tetramisole at 0.5 and 1mg/kg did not significantly affect general locomotor activity of the mice in 5-min open-field activity test or negative geotaxis performance and landing foot splay. However, the 1 mg/kg dose of tetramisole significantly increased the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Repeated tetramisole treatments (0.5 and 1 mg/kg) also significantly decreased the time needed to complete the negative geotaxis task and reduced landing foot splay[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.15mL 0.83mL 0.42mL |
20.77mL 4.15mL 2.08mL |
41.54mL 8.31mL 4.15mL |
| 参考文献 |
|---|