TYK2-IN-12

产品说明书

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Chemical Structure| 2244061-66-1 同义名 : -
CAS号 : 2244061-66-1
货号 : A1671859
分子式 : C24H20F2N4O2
纯度 : 98%+
分子量 : 434.44
MDL号 : N/A
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 TYK2-IN-12, an orally active, potent, and selective inhibitor of TYK2 (tyrosine kinase 2), with a Ki of 0.51 nM, inhibits IL-12-induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. It serves as a valuable tool for psoriasis research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.51mL

2.30mL

1.15mL

23.02mL

4.60mL

2.30mL
参考文献

[1]Leit S, et al. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett. 2022 Jul 13;73:128891.