产品说明书
NXPZ-2
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同义名 : | - |
| CAS号 : | 2254492-08-3 | |
| 货号 : | A1671504 | |
| 分子式 : | C27H27N5O7S2 | |
| 纯度 : | 98% | |
| 分子量 : | 597.663 | |
| MDL号 : | N/A | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NXPZ-2 functions as an orally active inhibitor of the Keap1-Nrf2 protein–protein interaction (PPI), with a Ki value of 95 nM and EC50 values of 120 and 170 nM. It exhibits dose-dependent improvement in Aβ[1-42]-induced cognitive dysfunction and mitigates brain tissue pathological changes in Alzheimer’s disease (AD) mouse models by augmenting neuron quantity and function. Additionally, NXPZ-2 inhibits oxidative stress by upregulating Nrf2 expression levels and facilitating its translocation from the cytoplasm to the nucleus, thereby aiding research on Keap1-Nrf2 PPI inhibitors and AD-associated diseases[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.67mL 0.33mL 0.17mL |
8.37mL 1.67mL 0.84mL |
16.73mL 3.35mL 1.67mL |
| 参考文献 |
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