产品说明书

Tildacerfont

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Chemical Structure| 1014983-00-6 同义名 : SPR001;LY2371712
CAS号 : 1014983-00-6
货号 : A1671111
分子式 : C20H26ClN5OS
纯度 : 99%+
分子量 : 419.971
MDL号 : N/A
存储条件:

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 9 mg/mL(21.43 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Tildacerfont is a potent, orally active CRF1 receptor antagonist. Tildacerfont is effective in reducing ACTH and adrenal androgen levels. Tildacerfont has a favourable safety profile and can be used to study congenital adrenal hyperplasia[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.91mL

2.38mL

1.19mL

23.81mL

4.76mL

2.38mL

参考文献

[1]Prete A, et al. Clinical advances in the pharmacotherapy of congenital adrenal hyperplasia. Eur J Endocrinol. 2021;186(1):R1-R14. Published 2021 Nov 30.