产品说明书
(2-Chloropyridin-4-yl)methanamine hydrochloride
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同义名 : | - |
| CAS号 : | 916210-98-5 | |
| 货号 : | A166155 | |
| 分子式 : | C6H8Cl2N2 | |
| 纯度 : | 95% | |
| 分子量 : | 179.047 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(195.48 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(279.26 mM) |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | (2-Chloropyridin-4-yl)methanamine hydrochloride is an inhibitor of LOXL2 with an IC50 value of 126 nM, showing greater selectivity for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO). In human whole blood assays for LOXL2, the IC50 of (2-Chloropyridin-4-yl)methanamine hydrochloride is 1.45 µM, compared to 126 nM in the absence of blood proteins. Its selectivity for LOXL2+BSA (IC50=190 nM) is 31 times greater than for LOX+BSA (IC50=5.91 µM). (2-Chloropyridin-4-yl)methanamine hydrochloride is inactive against a set of LTQ-free AO enzymes (MAO-A, MAO-B, and SSAO) at 30 µM. It also inhibits three different CYP enzymes (CYP 3A4, 2C9, and 2D6), with IC50 values all above 30 µM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.59mL 1.12mL 0.56mL |
27.93mL 5.59mL 2.79mL |
55.85mL 11.17mL 5.59mL |
| 参考文献 |
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